a few suggestions from a relatively new resident:
monkeytown is a nice, chill place to have dinner. there are projections on all 4 walls and these long couches you sit at that line the perimeter. but, it depends on if there's anything on the calender you'd want to check out - ranges from film screenings to video installations to music performances. its a vj's paradise, that's for sure.
dream house - this is a pretty mental sound installation by la monte young if psychoacoustics and walking around (or laying down and falling asleep in) droney rooms full of standing waves is your thing. it feels a lot less new agey than the web site looks (: actually its really cool, you walk around 'playing' the drones by nodding your head and such.. very out there!
le poisson rouge - another kinda cool venue to have a drink at. they have all different performances too so you'd check the calender. noticed afrika bambaataa coming up, i don't really know what he's up to these days..?
too bad there aren't any 8bit/chiptune shows coming up. those are really fun here.
the easy lover loft party on NYE seems good...
everything but the kitchen synchotron